Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition
نویسندگان
چکیده
منابع مشابه
Cognition, Reserve, and Amyloid Deposition in Normal Aging
OBJECTIVE To determine whether amyloid deposition is associated with impaired neuropsychological (NP) performance and whether cognitive reserve (CR) modifies this association. METHODS In 66 normal elderly controls and 17 patients with Alzheimer disease (AD), we related brain retention of Pittsburgh Compound B (PiB) to NP performance and evaluated the impact of CR using education and American ...
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Until recently, the study of hormonal influences in Alzheimer disease was limited to the role of sex steroids. Despite numerous epidemiological studies supporting a protective role for estrogen in Alzheimer disease, recent studies show that estrogen administration in elderly women increases the risk of disease. Reconciling these contradictory reports, we previously hypothesized that other hormo...
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Alzheimer's disease (AD), a progressive neurodegenerative disorder, accounts for approximately 60 percent of all victims of dementia and affects greater than 10 percent of the population over 65 years old. Although the cause is unknown, there is evidence that beta-amyloid plays an important role in its pathogenesis. The deposition of this type of amyloid in the brain and its implications in AD ...
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Dementia is common in Parkinson disease (PD), although its anatomic and pathologic substrates remain undefined. Recently, striatal abnormalities in Lewy body diseases have been described, but their clinical relevance is not clear. Thirty PD cases from the United Kingdom Parkinson's Disease Society Tissue Bank were grouped as demented (PDD; n = 16) and nondemented (PD; n = 14) based on a review ...
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Amyloid may cause widespread damage to the gastrointestinal tract. Affection of blood vessels may lead to infarction and perforation of the bowel (Brody, Wertlake, and Laster, 1964; Akbarian and Fenton, 1964) as well as to bleeding or loss of protein into the lumen of the gut (Jarnum, 1965); damage to the musculature or nervous elements may cause marked alterations in motility (Gilat and Spiro,...
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ژورنال
عنوان ژورنال: Journal of Neuroinflammation
سال: 2020
ISSN: 1742-2094
DOI: 10.1186/s12974-020-01915-0